From Chemistry Towards Technology Step-By-Step From Chemistry Towards Technology Step-By-Step От химии к технологии шаг за шагом 2782-1900 125733 Научные статьи Scientific articles Научные статьи Perspektivnyi podkhod k sintezu 2,5-dizameshchennykh 1,3,4 oksadiazolov Перспективный подход к синтезу 2,5-дизамещенных 1,3,4 оксадиазолов Юсифова Юлия Руслановна Yusifova Yulia Ruslanovna yuyusifova@yandex.ru Фирстова Анастасия Андреевна Firstova Anastasia Andreevna firstovaaa@ystu.ru

кандидат химических наук;

candidate of chemical sciences;

 Лебедев Антон Сергеевич Lebedev Anton Sergeevich

кандидат химических наук;

candidate of chemical sciences;

 Ярославский государственный технический университет Yaroslavl State Technical University Ярославский государственный университет им. П.Г. Демидова P.G. Demidov Yaroslavl State University 7 2 36 43 27 04 2026 28 05 2026 https://comincon.ru/en/nauka/article/125733/view

Разработан эффективный метод синтеза 2,5-дизамещенных 1,3,4 оксадиазолов, включающий получение исходных гидразидов ароматических кислот, их превращение в N-ацилгидразоны и последующую окислительную циклизацию с использованием системы I2/K2CO3 в среде ДМСО. Показано, что предложенный подход обеспечивает высокие выходы целевых 1,3,4-оксадиазолов (до 78%).

Разработан эффективный метод синтеза 2,5-дизамещенных 1,3,4 оксадиазолов, включающий получение исходных гидразидов ароматических кислот, их превращение в N-ацилгидразоны и последующую окислительную циклизацию с использованием системы I2/K2CO3 в среде ДМСО. Показано, что предложенный подход обеспечивает высокие выходы целевых 1,3,4-оксадиазолов (до 78%).

 1 3 4-оксадиазолы; циклизация твердофазный метод

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