From Chemistry Towards Technology Step-By-Step From Chemistry Towards Technology Step-By-Step От химии к технологии шаг за шагом 2782-1900 122135 Научные статьи Scientific articles Научные статьи SINTEZ, FLUORESTSENTNYE I ANTIBAKTERIAL'NYE SVOISTVA N-(2’-AMINOARIL)ZAMESHCHENNYKh 1,2,4-OKSADIAZOL-5(4N)-ONOV СИНТЕЗ, ФЛУОРЕСЦЕНТНЫЕ И АНТИБАКТЕРИАЛЬНЫЕ СВОЙСТВА N-(2’-АМИНОАРИЛ)ЗАМЕЩЕННЫХ 1,2,4-ОКСАДИАЗОЛ-5(4Н)-ОНОВ Шетнев Антон Андреевич Shetnev Anton Andreevich a.shetnev@list.ru

кандидат химических наук;

candidate of chemical sciences;

 Константинова Анна Сергеевна Konstantinova Anna Sergeevna

аспирант химических наук;

graduate student of chemical sciences;

 Романычева Анна Александровна Romanycheva Anna Aleksandrovna

кандидат биологических наук;

candidate of sciences in biology;

 Байков Сергей Валентинович Baykov Sergey Valentinovich

кандидат химических наук;

candidate of chemical sciences;

 Силин Александр Маркович Silin Aleksandr Markovich Калашников Павел Николаевич Kalashnikov Pavel Nikolaevich Ивановский Сергей Александрович Ivanovskiy Sergey Aleksandrovich s.ivanovskiy@yspu.org

кандидат химических наук;

candidate of chemical sciences;

 Корсаков Михаил Константинович Korsakov Mihail Konstantinovich

доктор химических наук;

doctor of chemical sciences;

 Санкт Петербургский государственный университет Санкт Петербург Россия Санкт Петербургский государственный университет Санкт Петербург Russian Federation Ярославский государственный педагогический университет им. К.Д. Ушинского Yaroslavl State Pedagogical University named after K.D. Ushinsky Санкт Петербургский государственный университет Россия Санкт Петербургский государственный университет Russian Federation Санкт-Петербургский государственный университет St. Petersburg State University 7 2 8 15 29 04 2026 08 06 2026 https://comincon.ru/en/nauka/article/122135/view

Синтезирован ряд из восьми новых 2’-аминоарилоксадиазол-5(4Н)-онов по реакции восстановления соответствующих нитропроизводных хлоридом олова (II). Изучены антибактериальные и флуоресцентные свойства производных. Найдено соединение с умеренной антибактериальной активностью в отношении чувствительного штамма грамположительной бактерии Staphylococcus aureus ATCC-25923 (3-амино-4-(3-(3,4-дихлорфенил)-5-оксо-1,2,4-оксадиазол-4(5H)-ил)-бензонитрил, МИК 64 мкг/мл). Соединения продемонстрировали слабые флуоресцентные свойства при облучении светом λ = 355 нм.

Sintezirovan ryad iz vos'mi novykh 2’-aminoariloksadiazol-5(4N)-onov po reaktsii vosstanovleniya sootvetstvuyushchikh nitroproizvodnykh khloridom olova (II). Izucheny antibakterial'nye i fluorestsentnye svoistva proizvodnykh. Naideno soedinenie s umerennoi antibakterial'noi aktivnost'yu v otnoshenii chuvstvitel'nogo shtamma grampolozhitel'noi bakterii Staphylococcus aureus ATCC-25923 (3-amino-4-(3-(3,4-dikhlorfenil)-5-okso-1,2,4-oksadiazol-4(5H)-il)-benzonitril, MIK 64 mkg/ml). Soedineniya prodemonstrirovali slabye fluorestsentnye svoistva pri obluchenii svetom λ = 355 nm.

 Оксадиазол-5(4Н)-он Восстановление Хлорид олова(II) Антибактериальная активность флуоресценция Oksadiazol-5(4N)-on Vosstanovlenie Khlorid olova(II) Antibakterial'naya aktivnost' fluorestsentsiya Работа выполнена при поддержке гранта СПбГУ № 126022017742-6 This work was supported by Saint Petersburg State University (project № 126022017742-6)

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