Assessment of the complex formation process in the “Lanthanum(III) chloride – ascorbic acid” system

Шубина Анна Александровна; Орлова Татьяна Николаевна

doi:10.52957/2782-1900-2026-7-3-198-207

УДК 54-386 УДК 546.654 УДК 615.213

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ASSESSMENT OF THE COMPLEX FORMATION PROCESS IN THE “LANTHANUM(III) CHLORIDE – ASCORBIC ACID” SYSTEM Assessment of the complex formation process in the “Lanthanum(III) chloride – ascorbic acid” system

АА Аа

Опубликовано в От химии к технологии шаг за шагом · Том 7, Номер 3, 2026 · Страницы 198–207 · Рубрика: Научные статьи

DOI: https://doi.org/10.52957/2782-1900-2026-7-3-198-207

Получено: 02.06.2026 Одобрено: 14.07.2026 Опубликовано: 02.10.2026 Язык публикаций: ENG

Авторы

ШУ

Шубина Анна Александровна

ОР

Орлова Татьяна Николаевна

ШУ

Шубина Анна Александровна

Ярославский государственный университет студент · Институт фундаментальной и прикладной химии · Россия · Ярославль

ОР

Орлова Татьяна Николаевна

Ученая степень: кандидат химических наук

Ярославский государственный университет канд. хим. наук, доцент · Институт фундаментальной и прикладной химии · Россия · Ярославль

АННОТАЦИЯ

The synthesis of a coordination compound of lanthanum(III) with L‑ascorbic acid was performed under mild conditions (ice bath, pH 7). The composition and structure of the complex were confirmed by elemental analysis, IR and UV‑Vis spectroscopy; the metal‑to‑ligand ratio was found to be 1:1. The instability constant of the compound was determined by spectrophotometry. Virtual screening using the PASS Online and ProTox resources was performed to forecast the biological activity and toxicological effects of free ascorbic acid and its lanthanum(III) complex. The complexation transforms the pharmacological profile. As a result, an antioxidant activity decreases and inhibition of NADPH oxidase, ubiquinol‑cytochrome C reductase and osmotic diuretic action occur. The toxicological profile of the complex is characterized by metabolic acidosis, hyperglycemia, and nephrotoxicity in the absence of cardiotoxicity, mutagenicity, and carcinogenicity. However, the forecast in terms of hepatotoxicity requires experimental verification. Therefore, further study of rare‑earth ascorbates as compounds with potential biological activity is promising one.

КЛЮЧЕВЫЕ СЛОВА

lanthanum, ascorbic acid, complexation, spectrophotometry, IR spectroscopy, virtual screening, PASS Online, ProTox, biological activity, toxicological profile.

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Текст (EN) (PDF)

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Главный редактор

Березин Дмитрий Борисович

Заместитель главного редактора

Абрамов Игорь Геннадьевич

abramovig@ystu.ru

Ответственный секретарь

Чиркова Жанна Вячеславовна

chirkovazhv@ystu.ru

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Контент доступен под лицензией Creative Commons «С указанием авторства версии 4.0 Международная» Creative Commons

ГОСТ

Шубина А. А., Орлова Т. Н. Assessment of the complex formation process in the “Lanthanum(III) chloride – ascorbic acid” system // От химии к технологии шаг за шагом. 2026. № 3. С. 198-207. DOI: https://doi.org/10.52957/2782-1900-2026-7-3-198-207. (дата обращения: 23.10.2026).

MLA

Шубина Анна Александровна, Орлова Т. Н.. "Assessment of the complex formation process in the “Lanthanum(III) chloride – ascorbic acid” system." От химии к технологии шаг за шагом 7.3 (2026): 198-207. DOI: https://doi.org/10.52957/2782-1900-2026-7-3-198-207.

APA

Шубина А. А., Орлова Т. Н. (2026). Assessment of the complex formation process in the “Lanthanum(III) chloride – ascorbic acid” system. От химии к технологии шаг за шагом, 7(3), 198-207. https://doi.org/10.52957/2782-1900-2026-7-3-198-207

Chicago

Шубина Анна Александровна, Орлова Т. Н.. "Assessment of the complex formation process in the “Lanthanum(III) chloride – ascorbic acid” system." От химии к технологии шаг за шагом 7, no. 3 (2026): 198-207. https://doi.org/10.52957/2782-1900-2026-7-3-198-207.

WIKI

{{cite journal | author = Шубина А. А., Орлова Т. Н. | title = Assessment of the complex formation process in the “Lanthanum(III) chloride – ascorbic acid” system | journal = От химии к технологии шаг за шагом | year = 2026 | volume = 7 | issue = 3 | pages = 198-207 | doi = 10.52957/2782-1900-2026-7-3-198-207 }}

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ASSESSMENT OF THE COMPLEX FORMATION PROCESS IN THE “LANTHANUM(III) CHLORIDE – ASCORBIC ACID” SYSTEM Assessment of the complex formation process in the “Lanthanum(III) chloride – ascorbic acid” system

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