from 01.01.2022 to 01.01.2024
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
UDC 546.654
UDC 615.213
Poluchen kompleks sostava [La(GBP)3]·3HCl·8H2O (GBP – gabapentin), v kotorom karboksilat-iony liganda koordiniruyutsya s ionom La3+ po bidentatnomu mostikovomu tipu. Kompleksoobrazovanie podtverzhdeno batohromnym sdvigom v UF-spektre (λmax = 302 nm), izmeneniem polos valentnyh i deformacionnyh kolebaniy v IK-spektre. Rasschitana konstanta nestoykosti (Knest = 1.16·10-10) poluchennogo soedineniya. Komp'yuternyy analiz vyyavil principial'noe izmenenie farmakologicheskogo profilya: kompleks s koordinacionnym chislom 3 demonstriruet rezko usilennyy anal'geticheskiy (Pa = 0.904) i novyy protivoopuholevyy effekt protiv mnozhestvennoy mielomy (Pa = 0.837) po sravneniyu s GBP. Parallel'no prognoziruetsya uluchshenie pronicaemosti cherez GEB (log BB > 0) i povyshenie affinnosti k mishenyam (pKi = 5.06). Odnako otmechaetsya rost riska gastrointestinal'noy toksichnosti (Pa = 0.798). Poluchennye dannye obosnovyvayut perspektivnost' dal'neyshih doklinicheskih issledovaniy kompleksa [La(GBP)3]3+ v kachestve mnogofunkcional'nogo agenta dlya lecheniya neyropaticheskoy boli, fobicheskih rasstroystv i onkologicheskih zabolevaniy, trebuyuschego, odnako, razrabotki special'nyh lekarstvennyh form dlya minimizacii prognoziruemoy ZhKT toksichnosti.
gabapentin, IK-spektroskopiya, elektronnaya spektroskopiya, lantan, koordinacionnoe chislo, ustoychivost' kompleksa, PASS-online, protivoopuholevaya aktivnost'
1. Bünzli J. C. G. Benefiting from the unique properties of lanthanide ions. Acc. Chem. Res., 2006, 39 (1), 53–61. DOI:https://doi.org/10.1021/ar0400894
2. David T., Šedinová M., Myšková A. Ultra-inert lanthanide chelates as mass tags for multiplexed bioanalysis. Nat. Commun., 2024, 15, 9836. DOI:https://doi.org/10.1038/s41467-024-53867-1
3. Zhang Q., O'Brien S., Grimm J. Biomedical applications of lanthanide nanomaterials, for imaging, sensing and therapy. Nanotheranostics, 2022, 6(2), 184. DOI:https://doi.org/10.7150/ntno.65530
4. Butranova O. I., Zyryanov S. K. Primenenie gabapentina dlya terapii neyropaticheskoy boli: vzglyad s poziciy dokazatel'noy mediciny. Farmaciya i farmakologiya, 2024, (1), 74-88. URL: https://cyberleninka.ru/article/n/primenenie-gabapentina-dlya-terapii-neyropaticheskoy-boli-vzglyad-s-pozitsiy-dokazatelnoy-meditsiny (data obrascheniya: 26.03.2026)
5. Frolova V. I., Gushanskaya E. V., Medvedev V. E. Ad'yuvantnaya terapiya depressiy preparatom gabapentin. STPN, 2023, (3–4), 27-34. URL: https://cyberleninka.ru/article/n/adyuvantnaya-terapiya-depressiy-preparatom-gabapentin (data obrascheniya: 26.03.2026)
6. Swetha G. A., Sachin H. P., Choudhuri J. R. Performance of an anticonvulsant drug, expired gabapentin, on zinc corrosion in an acidic environment. Emerg. Mat., 2023, 6 (2), 721–740. DOI:https://doi.org/10.1007/s42247-023-00481-4
7. Manna D., Ghanty T. K. Complexation behavior of trivalent actinides and lanthanides with 1,10-phenanthroline-2,9-dicarboxylic acid based ligands: insight from density functional theory. Phys. Chem. Chem. Phys., 2012, 14 (31), 11060–11069. DOI:https://doi.org/10.1039/C2CP40083A
8. Cherkasova E. V. Structural characteristics of (N-thiocyanato) chromates (III) of lanthanides (III) with pyridine-3-carboxylic acid. Russ. J. of Coord. Chem., 2025, 51 (7), 579–585. DOI:https://doi.org/10.1134/S1070328425600366
9. Gourdon L., Cariou K., Gasser G. Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review. Chem. Soc. Rev., 2022, 51 (3), 1167–1195. DOI:https://doi.org/10.1039/D1CS00609F
10. Lugones Y., Loren P., Salazar L. A. Cisplatin resistance: genetic and epigenetic factors involved. Biomolecules, 2022, 12 (10), 1365. DOI:https://doi.org/10.3390/biom12101365
11. Zhang Y. DNA binding studies and in-vitro anticancer studies of novel lanthanide complexes. Int. J. Biol. Macromol., 2024, 279, 135048. DOI:https://doi.org/10.1016/j.ijbiomac.2024.135048
12. Galaup C. Luminescent lanthanide complexes for reactive oxygen species biosensing and possible application in Alzheimer’s diseases. FEBS J., 2022, 289 (9), 2516–2539. DOI:https://doi.org/10.1111/febs.15859
13. Akitsu T. Lanthanide complexes in recent molecules. Molecules, 2022, 27 (18), 6019. DOI:https://doi.org/10.3390/molecules27186019
14. Hassan S. S. M., Mahmoud W. H. Spectrophotometric, potentiometric, and gravimetric determination of lanthanides with peri-dihydroxynaphthindenone. Anal. Chem., 1982, 54 (2), 228–231. DOI:https://doi.org/10.1021/ac00239a019
15. Blagojević D. Determination of chloride content in bottled mineral water. Acta Sci. Balcanica, 2022, 3 (1). DOI:https://doi.org/10.7251/ASB220301003B
16. OFS.1.2.1.0005.15 Rastvorimost'. Gosudarstvennaya farmakopeya Rossiyskoy Federacii [Elektronnyy resurs]. URL: https://pharmacopoeia.regmed.ru/ (data obrascheniya: 26.03.2026)
17. Bockbrader H. N., Wesche D., Miller R., Chapel S., Janiczek N., Burger P. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin. pharmacokinet., 2010, 49(10), 661-669. DOI:https://doi.org/10.2165/11536200-000000000-00000
