![Diastereoselective synthesis of chromeno[4,3-d]pyrimidines](/upload/12631c5e396938a702bdd516ae8c4208/issues/cover/aeeadbe79f068d9885fba8f04ac27a3b.png)
graduate student from 01.01.2023 until now
Yaroslavl State Technical University
student from 01.01.2018 to 01.01.2023
Yaroslavl, Yaroslavl, Russian Federation
graduate student
Yaroslavl, Yaroslavl, Russian Federation
Yaroslavl, Yaroslavl, Russian Federation
UDK 547.853.3 Пиримидин
The paper investigates the diastereoselective synthesis of chromeno[4,3-d]pyrimidines by isolation and cyclization of diastereomerically pure dihydropyrimidine addition intermediates to resorcinol. The authors discovered the reversibility of the addition reaction to be an important factor that could neutralize the dominant formation of one of the intermediate diastereomers.
hexahydrochromeno[4,3-d]pyrimidines, resorcinol, acid-catalyzed condensation, diastereoselectivity
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10. Filimonov, S.I., Chirkova, Zh.V., Kabanova, M.V., Makarova, E.S., Shetnev, A.A., Panova, V.A. & Suponitsky, K.Yu. (2019) A condensation of Biginelli products with 1,3-benzenediols: a facile access to diastereomerically pure hexahydro-5H-chromeno[4,3-d]pyrimidin-5-ones, ChemistrySelect., 4(33), pp. 9550 9555. DOI:https://doi.org/10.1002/slct.201901997 [online]. Available at: https://chemistry-europe.onlinelibrary. wiley.com/doi/10.1002/slct.201901997
11. Makarova, E.S., Kabanova, M.V., Filimonov, S.I., Shetnev, A.A. & Suponitsky, K.Yu. (2022) Synthesis and modification by hydroxyl group of substituted hexahydro-2H-chromeno[4,3-d]pyrimidin-2,5-diones, Izv. AN. Ser. khim., (5), pp. 1034-1042 (in Russian).
12. Filimonov, S.I., Makarova, E.S., Chirkova, J.V. & Kabanova, M.V. (2022) Diastereomeric composition of the reaction of the formation of hexahydro-5H-chromeno[4,3-d]pyrimidin-5-ones, From Chemistry Towards Technology Step-By-Step, 3(1), pp. 68-75 [online]. Available at: http://chemintech.ru/index.php/tor/2022tom3no1(accessed 14.02.2023) (in Russian).
