Ivanovo, Ivanovo, Russian Federation
employee
Ivanovo, Ivanovo, Russian Federation
employee
Ivanovo, Ivanovo, Russian Federation
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
UDK 544.353.2 Сольватация. Сольватная оболочка. Влияние оболочки. Эффект клетки
UDK 544.582.6 Изотопные эффекты
UDK 546.212.027 Тяжелая вода D2O
The paper considers the measurements of densities the pharmaceutical “teotro-pine” or tetramethylenediethylenetetramine (TMDETA) solutions in heavy water (D2O) with the solute molality from (0.01 to 0.12) mol∙(kg solvent) 1 at T = (278.15, 288.15, 298.15, 308.15, and 318.15) K and ambient pressure (p = 0.1 MPa). The uncertainty in density measured using the Anton Paar DMA 5000 M densimeter (equipped with oscillating U-tube) was 0.03 kg m-3 or lower. We obtain the standard (at infinite dilution) molar volumes and isobaric expansibilities of TMDETA as a solute in D2O, along with the corresponding solvent D2O–H2O isotope effects (IEs). We define the isotope effects using the previously ob-tained data on volumetric properties of the system (H2O + TMDETA). We also find that the insignificant IEs in the standard molar volume of TMDETA increase with increasing temperature. Based on the analysis of contributions to the standard molar volume of TMDETA in terms of the Scaled Particle Theory (SPT) we confirm that a bulkier molecule of this solute interacts with water (especially, in D2O) actively than it does with a molecule of hexamethylenetetramine (HMTA) or pharmaceutical “urotropine” being the related aminal (cage-like) compound. The colloborating discussion of volume- and enthalpy-isotope characteristics of TMDETA (and HMTA) hydration within the scope of SPT led us to the conclusion that the structure matrix of D2O is more efficient for incorporat-ing the bulkier TMDETA molecule into it
teotropine, standard volume and expansibility, standard enthalpy of dissolution, ordinary and heavy water, solvent H/D isotope effect
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